メチルビリジン誘導体の合成(第25報) : α-置換-2-pyridineacetonitrile誘導体の合成
1969 年 89 巻 2 号 p. 188-193
詳細
1969 年 89 巻 2 号 p. 188-193
Reaction of 2-pyridineacetonitrile (II) with aldehydes in the presence of sodium hydroxide or piperidine in ethanol gives α-alkylidene-2-pyridineacetonitrile (V). II does not react with ketones under the same condition but does react with benzophenone in the presence of sodium amide to give α, α-diphenyl-2-pyridineethanol (IX). II easily transits to α-acyl-2-pyridineacetonitrile (X) by reaction with acid halides. Catalytic reduction, hydrolysis, and Grignard reaction of V are also described.
