実験糖尿病におよぼす含硫化合物の影響(第3報) : 糖類の細胞膜通過に対するチオールおよびジスルフィド化合物の影響

抄録

1) Effect of SH and S-S compounds on the passage of sugars through the cell membrane was examined by the use of rat diaphragm and epididymal adipose tissue. 2) Both SH and S-S compounds, in the absence of insulin, accelerate the passage of sugars through the membrane and this accelerative effect is also observed in DNP and PCMB. 3) This accelerative action of SH and S-S compounds is also observed in alloxan-diabetes rat tissue, as well as in normal rats. 4) Sugars (L-arabinose, D-xylose) which have a stereospecificity in membrane passage and whose activity is accelerated by insulin are also accelerated by SH compounds. 5) Sugars in the cells are rapidly expelled outside the cells by SH compounds. From these results we discussed the way of action of thiol and disulfide compounds on the passage of sugars through the cell membrane in respect to the SH group of the cell membrane and the insulin action.