YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
ウラシル誘導体とその関連化合物について(第8報) : Bucolome関連化合物の合成と消炎作用その3
千田 重男和泉 弘藤村 一
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1969 年 89 巻 2 号 p. 260-265

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As the assumed metabolites of bucolome (I), the compounds (III to VI) formed by the oxidation of 5-butyl to 5-(3-oxobutyl), the compounds (XXI to XXIV) formed by the oxidation of 5-butyl to 5-(3-hydroxybutyl), and the compounds (XXVII and XXVIII) formed by the oxidation of 5-butyl to 5-(4-hydroxybutyl) group were synthesized. At the same time, a series of related compounds were systematically synthesized and the relationship between their chemical structure and their pharmacological action (anti-inflammatory activity) and acute toxicity was examined. XXII was identified as the main metabolite of bucolome by collaborators and details of this work will be published elsewhere.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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