(2-Bromoacyl) ureidesの生体内脱ブロム反応に関する研究(第3報) : (2-Bromoacyl) ureidesの非経口投与による尿中代謝物について

抄録

In the previous works of this series, ^{1, 3)} it was found that (2-bromoacyl) ureides administered orally were excreted as the corresponding debrominated metabolites in the urine of rabbits. The present investigation was undertaken in order to determine whether these metabolites were also found in the urine when the drugs were administered subcutaneously to rabbits at the dose of 100 mg/kg body weight. As the results, we found almost same amount of, debrominated metabolites as in the case of oral administrtion described in the previous paper, ^{1, 3)} and therefore it was concluded that most of the metabolites produced in vivo was not attributable to the action of intestinal bacteria.