芍薬の薬理学的研究(第1報) : ペオニフロリンの中枢作用および甘草成分FM100との併用効果

抄録

The pharmacological studies of central effects of herb paeony root, chiefly of its component paeoniflorin (Pae), were carried out. Herb paeony root is frequently used in chinese medicine. As licorice is one of the crude drugs which are frequently used in combination with paeony, combined effects of Pae with licorice component FM 100 were examined in order to investigate the combined effects of both crude drugs. Mice were used in these tests. The pharmacological effects of Pae are given as follows. The acute toxicity was very low. Sedative symptom was found. Loss of righting reflex was obtained in the rat by intraventricular administration. Sleeping duration induced by hexobarbital was prolonged. Writhing symptom induced by intraperitoneal administration of AcOH was inhibited. Weak hypothermia and weak anticonvulsive effect to pentylenetetrazol were found. The pharmacological effects of FM 100 are given as follows. Analgesia was found in both writhing test and tail-pressure test. This action was also obtained in the rat by intraventricular administration in the method which consists in pressing base of the fingers of the hind feet. Marked hypothermic and antipyretic effects and weak anticonvulsive effect to pentylenetetrazol were found by intraperitoneal administration. The combined effects of Pae with FM100 were shown as synergistic in almost all experiments.