YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
芍薬の薬理学的研究(第2報) : ペオニフロリンの抗炎症作用, 胃液分泌抑制作用, ストレス潰瘍予防作用, 抗利尿作用および甘草成分FM100との併用効果
高木 敬次郎原田 正敏
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1969 年 89 巻 7 号 p. 887-892

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Pharmacological studies of peony root, chiefly of its component paeoniflorin (Pae), were carried out : anti-inflammatory effect, inhibitory effect on gastric juice secretion, preventive effect on stress ulcer, antidiuretic effect and combined effects with licorice component FM100 had been studied. Pae showed a weak anti-inflammatory effect significantly inhibiting the rat paw edema induced by carrageenin and showing a tendency to inhibit dextran- or α-chymotrypsininduced edema and exudation of dye into the abdominal cavity of the mouse. Pae had also a preventive effect on stress ulcer in the rat. The combined effects of Pae with FM100 were obtained as synergistic in the tests to evaluate inhibitory effect on gastric and anti-inflammatory effect by intraperitoneal administration. In so far as our tests were concerned, the extract of peony root showed little effects by oral administration ; marked effects could not be obtained even by intraperitonael administration.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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