1969 年 89 巻 7 号 p. 887-892
Pharmacological studies of peony root, chiefly of its component paeoniflorin (Pae), were carried out : anti-inflammatory effect, inhibitory effect on gastric juice secretion, preventive effect on stress ulcer, antidiuretic effect and combined effects with licorice component FM100 had been studied. Pae showed a weak anti-inflammatory effect significantly inhibiting the rat paw edema induced by carrageenin and showing a tendency to inhibit dextran- or α-chymotrypsininduced edema and exudation of dye into the abdominal cavity of the mouse. Pae had also a preventive effect on stress ulcer in the rat. The combined effects of Pae with FM100 were obtained as synergistic in the tests to evaluate inhibitory effect on gastric and anti-inflammatory effect by intraperitoneal administration. In so far as our tests were concerned, the extract of peony root showed little effects by oral administration ; marked effects could not be obtained even by intraperitonael administration.