芍薬の薬理学的研究(第3報) : ペオニフロリンの循環呼吸器系および摘出臓器におよぼす作用

抄録

Pharmacological studies of peony component paeoniflorin (Pae) were carried out as for its effects on circulatory and respiratory systems, on isolated smooth muscle and skeletal muscle and on smooth muscle organs in situ. The effects of licorice component FM100 on isolated organs were examined as well. Pae showed no antitussive effect on the guinea pig and scarcely affected the respiration of the guinea pig. Pae showed hypotensive effect on the guinea pig which can be thought to be based on its peripheral vasodilation. Direct action on heart muscle and antifibrillatory effect on ouabain-induced arrhythmia in the guinea pig were scarcely found. Pae showed vasodilation of coronary vessel and hind limb of the dog. Relaxation and inhibition of movement and tonus of smooth muscle organs such as rat stomach or rat uterus were also found. The experiment in isolated organs revealed anti-oxytocic action in rat uterus only, suggesting some organ specificity. The relaxing effect of Pae on smooth muscle is assumed to be mainly musculotropic. FM100 showed anti spasmodic action in isolated guinea pig intestine and rat uterus, being synergistic with Pae. Pae is decomposed into desbenzoylpaeoniflorin and benzoic acid, but both compounds scarcely showed such pharmacological effects as Pae did.