1-置換2-ピペリドン類と塩化ホスホリルとの反応(第4報) : β-ケトアミドと4級塩の相互変換
1969 年 89 巻 8 号 p. 1045-1047
詳細
1969 年 89 巻 8 号 p. 1045-1047
1, 5-Dibenzyl-2, 3, 4, 4a, 5, 6, 7, 8 (or 2, 3, 4, 5, 6, 7, 8, 8a)-octahydrocyclobuta [1, 2-b : 3, 4-b'] dipyridin-1-ium salt (IIIb) was converted into 1-benzyl-2-(1-benzyl-2-oxo-3-piperidyl)-3, 4, 5, 6-tetrahydropyridinium salt (IV) by allowing it to stand for a week or so in 20% hydrochloric acid at room temperature. IV was also formed by heating 1-benzyl-3-(5-benzylaminovaleryl)-2-piperidone (IIb) hydrochloride at about 150° or by leaving it in ethanol at room temperature. IV was transformed into IIb by hydrolysis with alkali and into IIIb by treatment with phosphoryl chloride. It was clear from these results that IIb and IIIb were interconvertible via IV.
