1969 年 89 巻 9 号 p. 1283-1288
Effect of nonionic surface active agent (lauric diethanolamide; HS-12-P) and the effect of the concentration of hydrocortisone acetate-4-14C on the release of hydrocortisone from liquid vehicle to the human excised skin are described. The relationship between the release of hydrocortisone acetate and concentration of HS-12-P to the excised human skin was observed as shown in Fig.1. The results showed that the rate of the release of hydrocortisone acetate was increased with increasing concentration of HS-12-P up to 7% but, above that concentration, the rate was reduced. This reduction depends on the entrapment of hydrocortisone acetate in micelles. The rate of release of hydrocortisone acetate increased proportionally with increasing concentration of hydrocortisone acetate when using a liquid vehicles, i.e., liquid paraffin (Fig. 5), propylene glycol (30%) -H2O (70%) (Fig. 3), and HS-12-P (10%) -H2O (90%) (Fig. 4). It was suggested that the proportional relation between the concentration and rate of release of hydrocortisone acetate was not related to the solubilities of hydrocortisone acetate in each liquid vehicles.