合成Bradykinin Fragmentのラット後趾浮腫法における浮腫活性
1970 年 90 巻 12 号 p. 1494-1498
詳細
1970 年 90 巻 12 号 p. 1494-1498
Edema-producing activity of 35 synthesized bradykinin fragments was tested by administration of 10 μg to a rat hind paw and the result was compared with that of 10 μg of bradykinin. All the peptides showed edematous activity, the strongest being bradykinin-(7-9)-tripeptide which produced edema of a degree comparable to that produced by bradykinin. Bradykinin-(1-8)-octapeptide and-(3-8)-hexapeptide also had a strong edema action. There did not seem to be a distinct correlation between the number and kind of amino acids constituting the peptide and edematous activity.
