1970 年 90 巻 12 号 p. 1553-1555
Preparative methods for 2-aminomethyl-1, 1-diphenyl-1-butene (I), a hypertensive drug, were investigated. The following three-step method was suggested to be the most suitable for the preparation of I. The first process is to obtain 2-cyano-1, 1-diphenyl-1-butanol (II) by condensation of butyronitrile and benzophenone in the presense of sodium hydride (molar ratio, 1 : 2 : 2) at 90°. The second is the reduction of II by sodium borohydride-CoCl2 system (molar ratio, II : NaBH4 : CoCl2=1 : 10 : 2) in MeOH at 20° to 2-aminomethyl-1, 1-diphenyl-1-butanol (III), and the final step is the dehydration of III to I in a mixture of acetic acid and conc. hydrochloric acid (20 : 1).