1970 年 90 巻 5 号 p. 548-551
Effect of 2-amino-3-ethoxycarbonyl-6-benzyl-4, 5, 6, 7-tetrahydrothieno [2, 3-c] pyridine (Y-3642) on heat-induced hemolysis was studied and its results were compared with the pharmacological effect in vivo. Y-3642 had an affinity for erythrocytes and markedly inhibited heat-induced hemolysis of rat erythrocytes. The inhibition of heat-induced hemolysis by test compounds correlated well with the inhibiting activity on the carrageenin edema, and with analgesic activities on benzoquinone writhing in mice or on inflammatory pain of rat paw induced by carrageenin.