2-Amino-1,3-propanedithiolおよび関連化合物の合成

抄録

2-Amino-1, 3-propanedithiol (I) and its N-methyl (II), N, N-dimethyl (III) derivatives, and 4-dimethylamino-1, 3-dithiolane (nereistoxin) (IV) were synthesized, in relatively good yield, from dichloroacetone via the oxime or by the Leuckart method. I-HCl and II-HCl showed a considerable toxicity to mice (LD₅₀ (i.v.) : 11.5 mg/kg and 11.8 mg/kg respectively).