抗動脈硬化剤に関する研究(第1報) : Aryloxyisobutyrateの生理活性に関する研究
1970 年 90 巻 8 号 p. 921-925
詳細
1970 年 90 巻 8 号 p. 921-925
Following data have been obtained on hypocholesteremic and toxic effects of some derivatives of arylcarboxylic acid in rats. Compounds with X=Cl or CH3, Y=O and R=CH3 in the general formula, X-[chemical formula]-Y-C(R)·(CH3)COOC2H5 were effective, and the most potent effect was obtained when X=Cl. 2) It was found that some compounds with n=2 in the formula (Cl-[chemical formula]-O-C(CH3)2-COO)nR, were less toxic in acute and growth-inhibiting toxicity and more effective in hypocholesteremic activity. Among these compounds, 1, 3-propanediol bis(2-p-chlorophenoxyisobutyrate)(CLY-503) was better than clofibrate in respect to hypocholesteremic effect and toxicity. 3) General pharmacological activities, thought to be an adverse action, of CLY-503 were fewer than those of clofibrate, and hardly any appreciable effect was noted in ordinary dose levels, in its action on respiratory and circulatory functions.
