遠心法による薬剤粉末の付着力の測定(第2報) : 下地表面の状態と分離-残留率曲線の関連性

抄録

Adhesive forces between the particle and substrate (tablet) in a homogeneous system of potato starch, aspirin, and lactose were measured by the same method as reported previously. In order to examine the influences of the surface roughness of substrates on the separation force-particle residue curves, three kinds of size fraction were compressed under the same tabletting condition in each system, but the average separation forces f₅0 obtained from the regressed separation force-particle residue line on the log-normal paper did not depend on the surface roughness in any of the systems and were confirmed to be well reproducible. However, the surface roughness had an effect on the geometrical standard deviation σ_g of the average separation force f₅0, and it showed a different tendency in the case of potato starch from that of aspirin and lactose. These effects were discussed by the microscopic examination of each substrate.