含硫黄異節環状化合物の合成(第3報) : 4-Methyl-1,2,3,4-tetrahydrodibenzo-[c, kl]-1,4-diazepino[2,1-c]-1,4-thiazepinの合成
1971 年 91 巻 11 号 p. 1228-1232
詳細
1971 年 91 巻 11 号 p. 1228-1232
Dehydrative cyclization of 3-{10-(11-oxo-dibenzo[b, f]-1, 4-thiazepinyl)} propionic acid (IV), obtained by hydrolysis of 10-(β-cyanoethyl)dibenzo[b, f]-1, 4-thiazepin-11-one (III) with concentrated hydrochloric acid, with phosphorus pentoxide afforded 1, 2-dihydro-3H-dibenzo[c, jk]pyrido[2, 1-c]-1, 4-thiazepin-3, 12-dione (V). The Schmidt reaction of V gave 1, 2, 3, 4-tetrahydrodibenzo[c, kl]-1, 4-diazepino[2, 1-c]-1, 4-thiazepin-3, 13-dione (VI) and the methyl compound (XII) of VI was reduced with lithium alminium hydride to 4-methyl-1, 2, 3, 4-tetrahydrodibenzo[c, kl]-1, 4-diazepino[2, 1-c]-1, 4-thiazepine (I).
