第3級アミンオキシドに関する研究(第42報) : p-Toluenesulfonyl Chlorideの存在下におけるPyridine系N-オキシドと青化カリとの反応

抄録

Reaction of quinoline 1-oxide (I) with potassium cyanide in the presence of tosyl chloride was examined. Reaction in a mixture of chloroform and water gave not quinaldonitrile (II) but carbostyril, whereas II was formed in a good yield when tosyl chloride in ethanol was added at -10° to a mixture of I in ethanol and potassium cyanide in a small amount of water, followed by stirring the reaction mixture at the same temperature for 3 hours. The latter procedure was applied to some aromatic N-oxides of pyridine series and was found to be generally applicable (Table I).