ピペリジン誘導体の研究(第4報)3-Oxo-1-thia-4,8-diazaspiro [4,5] decane誘導体の合成研究 その2

抄録

8-Unsubstituted-3-oxo-1-thia-4, 8-diazaspiro [4, 5] decane derivatives (V) were prepared from the corresponding 8-alkoxycarbonyl derivatives (IIb, c) by the Method A (HBr-AcOH), method B₁ (KOH-iso-PrOH), or method B₂ (Claisen's alkali). V were also prepared by the reaction of 4-piperidone hydrochloride (VIII) with corresponding mercapto acids and primary amines (method C). Sulfoxides (VI) of V were prepared by method A or method D₁ (oxidation of V with H₂O₂), and sulfones (VII) were prepared by method A or method D₂ (oxidation of V with KMnO₄). VI and VII were not obtained by the method B₁ or B₂. 4-Oxo-1-thia-5, 9-diazaspiro [5, 5] undecane (V-35) was prepared by method A or method C, and the sulfone (VII-25) of V-35 was prepared by method A.