Quinoxaline誘導体に関する研究(第14報) : 2-置換-quinoxaline 4-OxideとAcetophenoneとの反応
1971 年 91 巻 7 号 p. 721-726
詳細
1971 年 91 巻 7 号 p. 721-726
Application of acetophenone to 2-substituted quinoxaline 4-oxides (I) in the presence of sodium amide in dehyd. benzene, under ice cooling, afforded 2-substituted 2-phenacyl-quinoxaline 4-oxides (II) in a fairly good yield. The compounds submitted to this reaction were 2-ethyl (Ia), 2-isopropy (Ib), 2-tert-butyl (Ic), 2-ethoxy (If), 2-benzyloxy (Ig), and 1-methyl-1, 2-dihydro-2-oxo (Ih), derivatives, which respectively afforded 3-ethyl (IIa), 3-isopropyl (IIb), 3-tert-butyl (IIc), 3-phenyl (IId), 3-methoxy (IIe), 3-ethoxy (IIf), 3-benzyloxy (IIg), and 4-methyl-2-phenacyl-3, 4-dihydro-3-oxo (IIh), derivatives.
