YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
Pyrimidine誘導体および関連化合物の研究(第74報) : Thiamine関連化合物とDialkyl Benzoylphosphonatesの反応(有機化学)
高見沢 映佐藤 久夫
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1972 年 92 巻 1 号 p. 27-31

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Reaction of thiamine analogs (Ib-d) with dialkyl benzoylphosphonates (IIa-b) in the presence of triethylamine afforded ring-expanded products, 1, 4-thiazine derivatives (IIIb-d), which were converted to monocyclic compounds (IVb-d) by hydrolysis. In the reaction of Ic-d with IIa-b, it was necessary to add IIa-b before triethylamine. It was found that the difference between the reaction behavior of Ia-b and that of Ic-d toward IIa-b is attributable to the substituents at the C-4 and C-5 positions which affect the reactivity at the C-2 position in the thiazolium ring.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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