1972 年 92 巻 1 号 p. 51-58
Nine kinds of 6-phenylimidazo [2, 1-b] thiazoles (III) were prepared in a good yield by treatment of 2-aminothiazoles (I) with phenacyl bromide in BuOH for 2 hr at 110-115°. 6-Methylimidazo [2, 1-b] thiazoles (IV) were prepared in a good yield by treatment of 2-imino-3-(2-propynyl)-4-thiazoline hydrobromides (II') with an equivalent amount of alkali in EtOH. Thiocyanation of III and IV was carried out by the bromine and urea method, and the corresponding 5-thiocyanato derivatives (V, X) were obtained in a good yield. Thiocyanation of 6-phenyl-2, 3-dihydro-imidazo [2, 1-b] thiazoles (XII) proceeded similarly, giving the 5-thiocyanatoderivatives (XIII) in a good yield. Some of the related bromo compounds were also prepared by bromination and by ring closure of bromothiazoles.