YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
複素環化合物のチオシアノ化反応に関する研究(第2報) : Imidazo[2,1-b]-thiazole誘導体のチオシアノ化反応(有機化学)
加納 三郎
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1972 年 92 巻 1 号 p. 51-58

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Nine kinds of 6-phenylimidazo [2, 1-b] thiazoles (III) were prepared in a good yield by treatment of 2-aminothiazoles (I) with phenacyl bromide in BuOH for 2 hr at 110-115°. 6-Methylimidazo [2, 1-b] thiazoles (IV) were prepared in a good yield by treatment of 2-imino-3-(2-propynyl)-4-thiazoline hydrobromides (II') with an equivalent amount of alkali in EtOH. Thiocyanation of III and IV was carried out by the bromine and urea method, and the corresponding 5-thiocyanato derivatives (V, X) were obtained in a good yield. Thiocyanation of 6-phenyl-2, 3-dihydro-imidazo [2, 1-b] thiazoles (XII) proceeded similarly, giving the 5-thiocyanatoderivatives (XIII) in a good yield. Some of the related bromo compounds were also prepared by bromination and by ring closure of bromothiazoles.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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