Studies on the Compounds Related to Colistin. V. : Synthesis and Pharmacological Activity of Colistin Analogues (Biological)

Abstract

A lysine-colistin, an analog of the natural antibiotic colistin, was synthesized by the cyclization of linear decapeptide obtained from acyl-tetrapeptide, formyl-tetrapeptide, and dipeptide by a stepwise reaction. Lysine-colistin is a new peptide containing six moles of lysine instead of six moles of α, γ-diaminobutyric acid in colistin. Lysine-colistin and linear acyl-decapeptide had the same antibiotic activity as colistin against many gram-negative bacterias.