心脈管系薬に関する研究(第7報) : 1-tert-Butylamino-3-[o-(tetrahydrofurfuryloxy)-phenoxy]-2-propanol Hydrochloride(Y-6124)のアドレナリンβ-受容体遮断作用

抄録

1-tert-Butylamino-3-[o-(tetrahydrofurfuryloxy) phenoxy]-2-propanol hydrochloride (Y-6124) antagonizes the adrenergic β-receptor stimulating action of isoproterenol or of epinephrine in the isolated atrial preparation of guinea pigs or in the isolated uterus preparation of a rat. In the open-chest dog, Y-6124 administered intravenously showed more potent activities than propranolol in inhibiting responses, especially heart rate increase, induced by isoproterenol or epinephrine, or by electrical stimulation of stellate ganglion. By oral administration, Y-6124 in such a low dose as 0.1 mg/kg, inhibited responses induced by isoproterenol. The compound had more potent inhibiting activities than propranolol on blood flow in the coronary artery or in the femoral artery of the anesthetized dog by intraarterial administration. Y-6124, like propranolol, may be a compound having a potent adrenergic β-receptor blocking activity but no stimulating action on the receptor.