5-Hydroxy-and Methoxy-1-(tert-aminoalkyl)-3,4-dihydrocarbostyrilの合成
1972 年 92 巻 6 号 p. 772-774
詳細
1972 年 92 巻 6 号 p. 772-774
5-Hydroxy-1-(tert-aminoalkyl)-3, 4-dihydrocarbostyrils (Va-f) and their methyl ethers (IVa-f) were prepared for evaluation of their pharmacological activities. Alkylation of 5-methoxy-3, 4-dihydrocarbostyril (III) with the tert-aminoalkyl chlorides in refluxing xylene in the presence of sodium hydride gave 5-methoxy-1-(tert-aminoalkyl)-3, 4-dihydrocarbostyrils (IVa-f) in 52-92% yields. Demethylation of IVa-f with 48% hydrobromic acid gave Va-f in 81-88% yields. The results are summarized in a Chart and Tables.
