チオールおよびジスルフィド化合物の研究(第1報)³⁵S-2-メルカプトプロピオニルグリシンの吸収, 分布, 代謝および排泄

抄録

Absorption, distribution, metabolism, and excretion of 2-mercaptopropionylglycine (MPG) were studied by giving 50 mg/kg of ³⁵S-labeled MPG to rats. The results are sammarized as follows : 1) MPG was readily absorbed from the gastrointestinal tract and reached the highest blood level shortly after administration. (15-30 min). MPG was rapidly excreted. Four hours after administration, 73% of the dose given intraperitoneally and 48% of the dose given orally were excreted in the urine. 2) In earlier period after administration (15-30 min), considerable accumulation of MPG was observed in the kidney, pancreas, adrenal, liver, etc. MPG remaining in these organs was less than 1 μg/g 24 hr after administration. 3) Distribution in blood was such that 30 minutes after intraperitoneal injection, about 70% of MPG was found in red cells. On the other hand, more than 60% of radioactivity was observed in the fraction of blood protein. Examination of subcellular distribution of MPG in the liver revealed maximum localization in mitochondria. 4) As for metabolites in urine, 6 spots were detected on thin-layer chromatogram. The main metabolites were 3 including MPG, its disulfide, and thiolactic acid. The other three were unidentified.