Abstract
Various substituted 4-cyanopyridines were prepared by the reaction of corresponding substituted 1-(N-methylacetamido) pyridinium salt and potassium cyanide in aqueous, solution. In this reaction, the pyridinium salt which had electron-withdrawal substituent at 3 and/or 5 position provided a mixture of 2- and 4-cyanopyridine derivatives but treatment with potassium cyanide in aqueous solution containing ammonium chloride afforded 4-cyanopyridine derivative alone. The 4-cyanopyridines so obtained were converted into 4-thiocarbonamides whose antituberculosic activity in vitro was tested.(The results are given in Table IV.)
