Benzylcarbonyl化合物とFormamideとの反応(第10報)α-Acyl-α-naphthylacetonitrileとの反応

抄録

α-Acyl-α-naphthylacetonitriles were heated with HCONH₂ and POCl₃, and the following results were obtained. 1) In the case of α-acyl-α-(1-naphthyl) acetonitriles, formyl derivative (IIa) gave 4-amino-5-(1-naphthyl) pyrimidine (IIIa), acetyl derivative (IIb) gave 4-amino-6-methy1-5-(1-naphthyl) pyrimidine (IIIb), and benzoyl derivative (IIc) gave IIIa and benzamide (IV). 2) In the case of α-acyl-α-(2-naphtyl) acetonitrilei, formyl derivative (VIa) gave 4-amino-5-(2-naphthyl) pyrimidine(VII), acetyl derivative (VIb) gave 6-methyl-5-(2-naphthyl)-4-pyrimidone.(VIII), and benroyl derivative (VIc) gave VII and IV.