1973 年 93 巻 4 号 p. 508-518
Several kinds of 3-(N, N-disubstituted amino)-1-phenylpropyl phenyl ethers were prepared according to the reaction scheme shown in Chart 1 (Substituted amino groups were dimethylamino, diethylamino, diisopropylamino, piperidino, morpholino, methylpiperidino, etc.). A related compound having a sulfonium group instead of amino group was also synthesized. In the case of 3-(2-methylpiperidino)-1-phenylpropyl phenyl ether and 3-(2-ethylpiperidino)-1-phenylpropyl phenyl ether, two kinds of diastereoisomers were respectively separated. The anticholinergic and mydriatic activities of 28 new compounds were examined. Piperidino, 2-ethylpiperidino, and 2-methylpiperidinopropyl phenyl ether derivatives showed a stronger activity than other compounds.