鎮痙作用を有する芳香族塩基性エーテルに関する研究(第2報)Alkyl or Aryl3-(N, N-Disubstituted Amino)-1-phenylpropyl Ether誘導体の合成と抗Ach作用

抄録

Alkyl or aryl 1-phenyl-3-piperidinopropyl ethers (2) and alkyl or aryl 3-(2-methylpiperidino)-1-phenylpropyl ethers (3) were systematically synthesized. These newly synthesized 68 compounds were subjected to anticholinergic and mydriatic examination. 2-Chlorophenyl 3-(2-methylpiperidino)-1-phenylpropyl ether methoiodide (64a) and 3-(2-methylpiperidino)-1-phenylpropyl 2-tolyl ether methobromide (61) showed one-half the anticholinergic activity of atropine sulfate and also 30-50 times the antibarium activity of papaverine hydrochloride.