YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
含窒素複素環式化合物の合成研究(第19報)4-Alkyl-5,8-disubstituted Amino-2-phenyl-3,4-dihydropyrimido[4,5-d]pyridazineの合成
万木 庄次郎伊藤 克己三宅 昭夫大村 晴
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1973 年 93 巻 8 号 p. 1043-1051

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The reaction of 5, 8-dimorpholino-2-phenyl-3, 4-dihydropyrimido[4, 5-d]pyridazine (IIa) with equimolar benzyl bromide and sodium hydride afforded 1-benzyl-5, 8-dimorpholino-2-phenyl-1, 4-dihydropyrimido[4, 5-d]pyridazine (IIIa), accompanied by a small amount of 3-benzyl-5, 8-dimorpholino-2-phenyl-3, 4-dihydropyrimido[4, 5-d]pyridazine (IVa). When IIa was treated with two equimolar benzyl bromide and sodium hydride, 1, 4-dibenzyl-5, 8-dimorpholino-2-phenyl-1, 4-dihydropyrimido[4, 5-d]pyridazine (Va) was formed in a good yield, which was converted to 4-benzyl-5, 8-dimorpholino-2-phenyl-3, 4-dihydropyrimido[4, 5-d]pyridazine (VIa), a diuretic agent, by hydrolysis with 10% HCl.

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