YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
Baumgarten法を利用するアミノ酸の不整合成
野上 靖純川副 裕一田口 胤三
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1973 年 93 巻 8 号 p. 1058-1063

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An asymmetric synthesis of α-amino acids was attempted through Neber rearrangement of (-)-menthyl N-chloroimidate by treatment with a base. As a result, L-phenylglycine, L-alanine, L-phenylalanine, and L-leucine were obtained, optical purity of the isolated products being 27%, 33%, 62%, and 75%, respectively. The asymmetric induction occurred to a much less extent, when (-)-2-methyl-1-butanol was used in place of (-)-menthol.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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