YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
Phenazine誘導体の金属キレートの研究(第8報)1-Hydroxyphenazineの金属錯体
喜谷 喜徳稲垣 健治小池 久
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1973 年 93 巻 9 号 p. 1089-1093

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Acid dissociation constant (pKa) of 1-hydroxyphenazine and stability constants of its metal complexes with bivalent metals such as Cu, Ni, Co, Zn, and Cd were determined by spectrophotometry in 50% (v/v) ethanol. It was found that pKa of 1-hydroxyphenazine was 9.21 and stability constants of these complexes were similar to those of 5-hydroxyquinoxaline-metal complexes, being smaller than those of 8-hydroxyquinoline-metal complexes. The binding ratio of 1-hydroxyphenazine-metal complexes was 2 : 1 from elemental analyses and mass spectrum. In its mass spectrum, the fragmentation of these 2 : 1 metal complexes was in good agreement with those of 8-hydroxyquinoline-metal complexes.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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