YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
鎮痙作用を有する芳香族塩基性エーテルに関する研究(第3報)Alkyl or Aryl 3-(2-Methylpiperidino)-1-phenylpropyl Ether誘導体の立体配位について
吉田 昭義守田 実小川 俊太郎
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1973 年 93 巻 9 号 p. 1138-1143

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Configurational analyses for the diastereoisomers of 1-chloro-3-(2-methylpiperidino)-1-phenylpropane (3α, 3β), alkyl or aryl 3-(2-methylpiperidino)-1-phenylpropyl ethers (C), and their quaternary bases (D) were carried out by measuring their nuclear magnetic resonance spectra. Each of amino chlorides (3α, 3β) and aminoethers (C) was found to be a single diastereoisomer. Quaternisation was found to introduce an axial methyl group into nitrogen of the piperidine ring.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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