YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
Amidinohydrazone類の抗菌性(第2報)Alkoxyacetophenone Amidinohydrazoneの抗菌性
西村 民男徳 広茂吉井 新守重 三枝
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1973 年 93 巻 9 号 p. 1242-1246

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The relationship between the chemical structure and antibacterial activity of alkoxyacetophenone amidinohydrazones was studied. m- or p-Alkoxy compounds showed maximum antibacterial activities with carbon atoms in the alkoxy group, and o-alkoxy compounds with 8-10 carbon atoms. Substitution of -NH2 with -[chemical formula], -[chemical formula] or -[chemical formula] in amidino moiety generally lowered the activity. Antibacterial potency of these compounds against gram-positive bacteria (G+), gram-negative bacteria (G-), and fungi. (F) decreased in this order but compounds having -[chemical formula] or -[chemical formula] at amidino moiety showed the order of G+>F>G-.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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