YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
Amidinohydrazone類の抗菌性(第3報)AlkoxybenzaldehydeおよびCinnamaldehyde Amidinohydrazoneの抗菌性
西村 民男吉井 新徳 広茂渡辺 満
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1973 年 93 巻 9 号 p. 1247-1250

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The relationship between the chemical structure and antibacterial activity of amidino-hydrazones of alkoxybenzaldehydes and alkoqcinnamaldehydes was studied. Although there were a few exception, o-alkoxybenzaldehyde amidinohydrazones showed maximum antibacterial activity with a carbon number of 10, m- or p-alkoxybenzaldehyde amidino-hydrazones with a carbon number of 6 and p-alkoxycinnamaldehyde amidinohydrazones with a carbon number of 5. Antibacterial potency of alkoxybenzaldehyde unsubstituted amidinohydrazones fell in the order of para, meta and ortho. Substitution of -NH2 with [chemical formula] of amidino moiety in o-alkoxybenzaldehyde amidinohydrazones increased the antibacterial potency against gram-positive bacteria and fungi.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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