ラット肝ミクロゾームおよび可溶性画分における脂質過酸化物の含量(in Vivoにおけるアスコルビン酸, Fe²⁺の影響について)

抄録

1) An in vivo study was made on the effect of ascorbic acid and ferrous ion on the formation of lipid peroxide on the rat liver microsomes and soluble fraction. Lipid peroxide content in microsomes and soluble fraction increased gradually with time after intraperitoneal administration of ascorbic acid (176 mg/kg/day) and ferrous chloride (28.2 mg Fe²⁺/kg/day). 2) Among the composition of phosphatidylserine and phosphatidylinositol, diminution of arachidonic acid and docosahexaenoic acid was predominant during increase in the formation of lipid peroxide in microsomes and soluble fraction. 3) Total sulfhydryl content of microsomes and soluble fraction decreased markedly by the application of ascorbic acid and ferrous ion.