YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
1,3-二置換1,2,3,4-テトラハイドロ-β-カルボリン誘導体の合成およびその立体異性体の研究
濱口 文子長坂 達夫大木 貞雄
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1974 年 94 巻 3 号 p. 351-358

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Some 1, 3-disubstituted 1, 2, 3, 4-tetrahydro-β-carboline derivatives were synthesized by the Pictet-Spengler reaction with DL-tryptophan methyl ester and aldehydes. They were separated into their stereoisomers by alumina column chromatography, and their configuration (cis and trans) was examined from their nuclear magnetic resonance spectra and those of their acetates. By the application of the above result, azoninoindole derivatives (11 and 12) were synthesized.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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