YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
(3-Amino-2-hydroxy)propoxy-3,4-dihydrocarbostyril誘導体の麻酔犬におけるβ-受容体遮断作用
中川 量之村上 七美吉崎 国郎富永 道明森 英雄藪内 洋一新谷 成之
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1974 年 94 巻 5 号 p. 613-616

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Anti-isoproterenol activity of 51 derivatives of 5-, 6-, 7-, and 8-(3-amino-2-hydroxy)-propoxy-3, 4-dihydrocarbostyril was measured in an anesthetized dog. The derivatives which had 3-tert-butylamino-2-hydroxypropoxy in 5 or 8 position showed a potent activity. Among them, 5-(3-tert-butylamino-2-hydroxy)propoxy-3, 4-dihydrocarbostyril hydrochlo-ride (6) proved to be the most effective. 6 may be the most hopeful compound as an adrenergic β-receptor-blocking agent.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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