YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
Keteneおよびその誘導体の研究(第61報)第一アミンとChloroketene Diethylacetalとの反応
加藤 鉄三山本 豊武田 四郎
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1974 年 94 巻 5 号 p. 627-632

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The reaction of chloroketene diethylacetal (I) with heterocyclic primary amines was studied. Reaction of aniline (IIa) with I afforded ethyl N-phenylchloracetimidate (III) in a good yield. However, 2-aminopyridine (IIb) and 2-aminoquinoline (IIc) reacted with I to give imidazo[1, 2-a]pyridine derivatives (IV, V, and VI) and imidazo[1, 2-a]quinoline derivatives (XI, XII, XIII, and XIV), respectively. On the other hand, reaction of 2-aminothiazole (IId) and 2-aminopyrimidine (IIe) with I afforded 2-chloro-1, 1-diethoxy-ethylamine derivatives (XVIII, XXI), which were easily converted to the corresponding iminoether derivatives (XIX and XXII), respectively.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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