Biological Active Principles of the Crude Drugs. II. Antiulcerogenic and Anti-inflammatory Actions of the Crude Drugs contained Saponin

Abstract

The antiulcerogenic and anti-inflammatory activities of saponin have been examined by oral administration in rats. Saponins for "Tochinoki" (Aesculus turbinata Br.), "Saikachi" (Gleditschia japonica MIQ.), and "Mi" (Madhuca longifolia L.) were active in both tests and the potency of anti-inflammatory activity of these saponins was about one-fifth that of phenylbutazone. On the other hand, deacylated derivative of saponin and sapogenol were generally found much less reactive.