Kessoglycol誘導体の合成とスクリーニング

抄録

Kessoglycol 2-acetyl-8-acylates (III-1 to -17), kessoglycol 8-acylates (VI-1 to-5), and kessoglycol 2, 8-diacylates (V-1 to -5) were prepared in order to examine their sedative effect in mice comparing with that of kessoglycol 2, 8-diacetate (I), to prolong the sleeping time induced by sodium hexobarbitate administered orally. III-1 to III-17 were found to be less effective, but V-3 and VI-3 were equal or more effective than I. The structure-activity relationship of these compounds was not established as yet.