抗炎症薬に関する研究(第28報)2-(5H-[1]Benzopyrano[2,3-b]pyridin-7-yl)propionic Acid(Y-8004)の家兎の局所シュワルツマン反応および多核白血球Lysosomeに対する作用

抄録

Endotoxin was injected intradermally to rabbits. Within 12 hr after this treatment, administration of 2-(5H-[1]benzopyrano[2, 3-b]pyridin-7-yl)propionic acid (Y-8004) was started. Y-8004 as well as indomethacin was found to inhibit the local Shwartzman reaction. Within 23 hr after the injection of endotoxin, administration of steroidal antiinflammatory drugs such as prednisolone were started and its results were similar to that of Y-8004, although the cell infiltration at the injection site of endotoxin was markedly observed at 23 hr after the injection of endotoxin. In addition, the leucocyte and lysosome suspension were prepared from the emigrated polymorphonuclear leucocytes of rabbits. Y-8004 and nonsteroidal acidic anti-inflammatory drugs inhibited the release of lysosomal enzymes both from the leucocytes by phagocytosis and from the lysosomes by incubation in vitro. However, steroidal antiinflammatory drugs did inhibit not only the above release reaction, but also the release of enzymes from the preincubated lysosomes. Based on these evidences, discussion was extended on the possible mechanisms of the inhibitory action of Y-8004 and anti-inflammatory drugs against the local Shwartzman reaction.