複素環化合物の研究(第4報) 2-(2,6-Dichlorobenzylidenehydrazino)-1,4,5,6-tetrahydropyrimidine Hydrochlorideおよび関連ヒドラゾン化合物の幾何異性体
1976 年 96 巻 2 号 p. 125-131
詳細
1976 年 96 巻 2 号 p. 125-131
The structure of a mild and durable antihypertensive agent, 2-(2, 6-dichlorobenzylidenehydrazino)-1, 4, 5, 6-tetrahydropyrimidine hydrochloride (IIIa) (OT-24) was established by nuclear Overhauser effect (NOE) experiments. The anti-isomer (IIIa) was found to easily isomerize to the syn-isomer (IIIb) by irradiation of an ultraviolet ray on aqueous and methanol solution. Several related hydrazones were synthesized and their configuration was examined.
