Triazine系化合物の薬理学的研究(第1報) 一般薬理作用の検討

抄録

Pharmacological properties of 32 s-triazine derivatives were examined and it's results are summarized as follows. 1) Twenty compounds showed depressant action against spontaneous motor activity. Among these, 4-substituted-2-amino-6-trifluoromethyl-s-triazine derivatives, I (4-iso-propylamino), IV (4-cyclohexylamino), IX (4- (4-methylpiperazin-1-yl)), X (4- (4- (2-hydroxyethyl)-piperazin-1-yl)), and 2-benzalhydrazino-4-tert-butyl-6-piperazino-s-triazine (XXXV) showed a significant effect below the dose level which caused muscle relaxation. 2) IV, X, and 2-hydrazino-4-piperazino-6-trifluoromethyl-s-triazine (XV) showed a significant anti-morphine action. 3) IX, 2-hydrazino-4-(4-acetylpiperazin-1-yl)-6-trifluoromethyl-s-triazine (XIII), 2-hydrazino-4-(4-methylpiperazin-1-yl)-6-trifluoromethyl-s-triazine (XIV), 2-benzalhydrazino-4-(4-(2-hydroxyethyl)-piperazin-1-yl))-6-trifluoromethyl-s-triazine (XXXIII), and XXXV strongly potentiated hexobarbital sleeping time. 4) Central depressant action of triazine derivatives was mainly characterized by sedative action accompanied by weak muscle relaxant and faint anti-convulsant action. Considering these results, it seems difficult to define the triazine derivatives as a specific type of a tranquilizer, although, IX, X, and XV exhibited cataleptogenic activity typical of major tranquilizer. 5) IX, X, and XXXV inhibited acetic acid-induced writhing and their activity was comparable to that of aminopyrine. 6) 2-Amino-4-p-chloroanilino-6-trifluoromethyl-s-triazine (VI), XIV, and 2-benzalhydrazino-4-morphorino-6-trifluoromethyl-s-triazine (XXX) showed moderate hypotensive actions. 7) I, IV, XIV, 2-isopropylamino-4-morphorino-6-trifluoromethyl-s-triazine (XLI), and 2-isopropylamino-4-methylamino-6-trifluoromethyl-s-triazine (XLIII) showed adrenolytic activities. 8) 2-Amino-4-phenethylamino-6-trifluoromethyl-s-triazine (V), 2-dimethylamino-4-(4-methylpiperazin-1-yl)-6-trifluoromethyl-s-triazine (XXXIX) and XLIII expressed moderate anti-serotonin effects but anti-cholinergic or anti-histaminic actions were not observed.