抗生物質Aminosidin(Paromomycin)に関する研究(第3報)アミノ酸誘導体とその生物活性
1976 年 96 巻 5 号 p. 557-564
詳細
1976 年 96 巻 5 号 p. 557-564
Amino acid derivatives of Aminosidin (Paromomycin) were prepared. Eight kinds of amino acid were introduced into the amino group in 6-position of the 2, 6-diamino-2, 6-dideoxy-D-glucose moiety of Paromomycin by the active esterification method. All the derivatives prepared have an antimicribial activity but less than that of the original antibiotic. Acute toxicity of the derivatives of glycyl and DL-γ-amino-β-hydroxybutyl Paromomycin was also less than that of the original antibiotic.
