タンニン酸およびタンニン酸殿粉の実験的消化性潰瘍に対する効果

抄録

Tannic acid has an inhibitory effect against the proteolytic activity of pepsin in vitro, but its activity was nonspecific. In pylorus-ligated rat, tannic acid inhibited not only peptic activity but also gastric acid secretion. However, the volume of gastric juice was not influenced by tannic acid. Tannic acid showed antiulcer activity by its oral administration (50 mg/kg) in Shay's ulcer. By the use of artificial gastric juice perfusion technique, formation of ulcer was delayed by the addition of tannic acid in the perfusate. The acetic acid ulcer was slightly healed by the oral administration of tannic acid (200 mg/kg) for 10 days without any effect on the growth curve of rats. Tannic acid formed a precipitate with starch in water and this complex has the same activities. From these results, it is suggested that tannic acid has ideal properties as an antiulcer agent.