6-Chloro-5-cyclohexyl-1-indancarboxylic acid (Ib), a potent nonsteroidal analgesic, antipyretic, and antiinflammatory agent, and related compounds were synthesized by the new routes via cyanation of 1-chloro-5-cyclohexylindan (IXa), which was obtained from 5-cyclohexyl-1-indanol (VIa), or cyanation of 1, 6-dichloro-5-cyclohexylindan (IXb), which was obtained from VIa or IXa.
