YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
茵〓蒿の研究(第1報) : 新利胆成分Capillarisin
小宮 威彌津久井 誠大塩 春治
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1976 年 96 巻 7 号 p. 841-854

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A new choleretic substance, capillarisin (I), was isolated from the herb of Artemisia capillaris Thunb. (Japanese name, "Inchinko" ?? 〓 ?? ) by tracing the activity in rats. By heating with 1% NaOH or H2SO4 in methanol, I was cleaved to p-hydroquinone and a compound (XI) or p-hydroquinone and the compound (XII). Infrared and ultraviolet spectra suggested that I and XI are chromone derivatives and XII is a coumarin derivative. Positions of the functional groups in XI and XII were determined by direct comparison with the synthetic samples, and the structure of I was established as 2-(p-hydroxy-phenoxy)-6-methoxy-5, 7-dihydroxychromone.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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