YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
3-Acetyltetramanilideとベンツアルデヒドの縮合反応における触媒選択性
山口 達明斉藤 仁俊木曽 幸一竹下 優辻本 利雄由岐 英剛
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1976 年 96 巻 7 号 p. 927-931

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The base-catalysed reaction of 3-acetyltetramanilide (II) with benzaldehyde in refluxing ethanol gave two isomeric condensation products. This indicates that both the ring methylene group (5-position) and the methyl group in α-phenylaminoethylidene group of II have the possibility of being attacked by the benzaldehyde molecule. Ratio of their yield varied with the nature of the base, the basicity and the steric requirement. Differences in the selective catalytic action between pyridine and piperidine are discussed on the basis of the results on the catalytic H-D exchange rate of the CH bonds of II susceptible to the condensation reaction.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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