YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
Sodium Borohydrideの反応(第3報)芳香族ニトロ化合物のSodium Borohydrideによる還元反応
野瀬 敦子工藤 忠宏
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1977 年 97 巻 1 号 p. 116-120

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Azoxybenzene(II), azobenzene(III), and aniline(IV) were formed by the reaction of nitrobenzene(I) with sodium borohydride at 180-200° in the absence of a solvent. In this reaction, increasing concentration of sodium borohydride increased the yield of IV and decreased that of II. Similarly, reduction of o-nitrotoluene(V), m-nitrotoluene(VI), p-nitrotoluene(VII), p-methoxynitrobenzene(VIII), and p-chloronitrobenzene(IX) gave the corresponding amine and azo derivatives. In order to clarify this reaction mechanism, the same reaction of reduced derivatives, such as nitrosobenzene(XX), N-phenylhydroxylamine (XXI), hydrazobenzene(XXII), and III, was examined and all these derivatives gave IV, but its yield was poor in the reduction of III.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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